News

Our collaborative work with Valkenier’s lab has just been published in OBC!

The study reveals two distinct HCO3‾ transport mechanisms by simple di(thio)amidocarbazoles as well as their potent antimicrobial properties. Read more here.

“New Ideas” grant for the Supramolecular Chemistry Laboratory

Anions are typically too hydrophilic to freely pass through biological membranes. This also applies to those drugs that are anionic at physiological pH. Synthetic anion transporters, i.e. small, lipophilic molecules that facilitate diffusion of anions across lipophilic barriers, may accelerate the diffusion of anionic drugs by many orders of magnitude and thus could dramatically increase their effectiveness. Moreover, transporters whose activity could be controlled by light, pH or other stimuli could enable the targeted delivery of drugs to the desired place and at the right time. The aim of this project is to develop the first switchable transporters for anionic drugs, and hence to demonstrate a new strategy for targeted drug delivery. As part of it, we will undertake research on the construction of transporters switchable by changes in pH or irradiation with light of a specific wavelength. We hope that this research will lead to the development of a new strategy for smart drug delivery, which may find practical applications in the future, e.g. in the treatment of cancer.

Open postdoctoral positions in the OPUS project

We are looking for 2 postdoctoral researchers for a groundbreaking research project on the border of organic, medicinal, and supramolecular chemistry.

The aim of the project is to develop small organic molecules capable of selectively transporting biologically relevant anions through lipid bilayers. Such molecules may exhibit interesting anti-cancer, antibacterial and antiviral properties, and may also find applications in the treatment of numerous diseases resulting from the dysfunction of natural transporters. Within the project, we would also like to construct stimuli-responsive transporters whose activity could be controlled by pH, light, or redox potential.

Successful candidates will design and synthesize novel anion receptors, study their anion binding properties and investigate their ability to transport anions through the lipid bilayers of model liposomes.

We offer:

  • a full-time employment contract for 12 months with a possible extension. Expected starting date: August 2022 (subject to negotiations)
  • state-of-the-art facilities in the new building of the Biological and Chemical Research Centre (more information and photographs at www.mchmielewski.pl)
  • a 6-7 person project team consisting of the PI (Dr. Michał Chmielewski), 2 post-docs, 2 doctoral students, and 1-2 graduate students
  • attractive salary (PLN 10 000 gross-gross/month)

Deadline for applications: 16 July 2022. More details in the following Announcement.

We discovered a pH-switchable chloride transporter with physiologically relevant apparent pKa

Chloride transporters have been intensely investigated because of their potential medicinal applications. In particular, pH-switchable transporters are highly appealing as potential anticancer agents, because they might be more active in cancer cells than in normal cells. Owing to its increased acidity, our simple 3,6-dinitro substituted carbazole receptor acts as a pH-switchable transporter, with physiologically relevant apparent pKa of 6.4. Read more in our newest paper in special issue of Frontiers in Chemistry, devoted to anion transport:

Maslowska-Jarzyna, M. L. Korczak, M. J. Chmielewski, “Boosting Anion Transport Activity of Diamidocarbazoles by Electron Withdrawing Substituents” Front. Chem., 2021, 9:690035.

NCN fellowships for students are available! (In organic/materials chemistry)

We invite students interested in collaboration on a ground-breaking research project on the border of organic and material chemistry. Attractive fellowships are available!

Poszukujemy studentów do współpracy przy realizacji przełomowego projektu badawczego z pogranicza chemii organicznej i materiałowej. Atrakcyjne stypendia czekają!

Celem projektu jest stworzenie zupełnie nowej klasy ‘inteligentnych’ materiałów porowatych, łączących trwałość MOF-ów ze zdolnością do odpowiedzi na bodźce i adaptacji do środowiska zewnętrznego. W ramach projektu zamierzamy też opracować nową strategię konstruowania MOF-ów przewodzących prąd elektryczny do zastosowań w bateriach i superkondensatorach.

Oferujemy:

  • możliwość udziału w potencjalnie przełomowych badaniach prowadzonych we współpracy z wiodącymi ośrodkami naukowymi
  • pracę w nowoczesnych i znakomicie wyposażonych laboratoriach zlokalizowanych w nowym budynku Centrum Nauk Biologiczno-Chemicznych UW
  • szansę na publikacje w prestiżowych czasopismach
  • możliwość przygotowania pracy dyplomowej związanej z tematyką grantu
  • pracę w zespole projektowym złożonym z kierownika projektu (MCh), 1 post-doca z wieloletnim doświadczeniem w tematyce grantu, 2 doktorantów i studentów
  • stypendia NCN w wysokości 1500 zł netto/mc na 10 miesięcy

Termin nadsyłania zgłoszeń – 10.12.2021. Więcej szczegółów tu: Ogłoszenie.

Our first joint paper with prof. Mircea Dincă from MIT has just been published in ACIE

Electrically conductive metal-organic frameworks (MOFs) are a fascinating class of porous conductors with many potential applications, such as chemiresistive sensing, electrochemical energy storage, and electrocatalysis. Owing to the Bekker fellowship from the Polish National Agency for Academic Exchange (NAWA), Dr. Michał Chmielewski spent 7 months in the laboratory of one of the pioneers and leaders of the development of these materials, prof. Mircea Dincă from Massachusetts Institute of Technology. The first results of this collaboration have just appeared in Angewandte Chemie International Edition:

Expanding the scope of anion transport studies

Drugs, metabolites, and other biologically relevant anionic species can be rapidly transported through biological membranes by a simple di(thioamide) receptor developed in our laboratory. In collaboration with the group of professor Alexander Kros from Leiden University, we have also shown that the transport kinetics of these anions can be easily quantified in both large and giant unilamellar vesicles (LUVs and GUVs).

Graphical abstract: Oxyanion transport across lipid bilayers: direct measurements in large and giant unilamellar vesicles

A new method for simple immobilisation of transition metal catalysts in MOFs

Simple acid−base reaction between commercially available amino-tagged Ru olefin metathesis catalyst and highly acidic, easily available, and extremely stable MOF, (Cr)MIL-101-SO3H, has been successfully employed for a very robust immobilization of the catalyst even in polar, “green” solvents. Using this catalyst, essentially ruthenium free (<10 ppm) olefin metathesis products can be obtained upon simple filtration. What is more, the immobilized catalyst shows higher activity in comparison to the unsupported catalyst. For details, see our contribution to a special issue of Organometallics dedicated to organometallic chemistry within Metal–Organic Frameworks (MOFs):

Figure 1